HER-2/neu Detection in Fine-Needle Aspirates of Breast Cancer
نویسندگان
چکیده
منابع مشابه
Computerized Diagnosis of Breast Fine-Needle Aspirates
The goal of this work is to determine the accuracy of computer-based image analysis in diagnosing breast fine-needle aspirates (FNA). On 192 FNAs, the computerbased diagnostic accuracy was 97.9%. This is consistent with the 97.5% accuracy projected by machine learning methods during the initial training in 1994 with 569 FNAs. One of the attributes of this system is the rendering of a value that...
متن کاملDetection of mitochondrial DNA mutations in primary breast cancer and fine-needle aspirates.
To determine the frequency and distribution of mitochondrial DNA mutations in breast cancer, 18 primary breast tumors were analyzed by direct sequencing. Twelve somatic mutations not present in matched lymphocytes and normal breast tissues were detected in 11 of the tumors screened (61%). Of these mutations, five (42%) were deletions or insertions in a homopolymeric C-stretch between nucleotide...
متن کاملHER-2/neu amplification detected by fluorescence in situ hybridization in fine needle aspirates from primary breast cancer.
BACKGROUND The HER-2/neu gene is amplified in 20-30% of human breast cancers and has been shown to have prognostic and predictive value for treatment with chemotherapy, hormone therapy and antibodies against the HER-2/neu domain (trastuzumab). The aim of our study was to evaluate the reliability of HER-2/neu determination by fluorescence in situ hybridization (FISH) on fine-needle aspirates (FN...
متن کاملAtypia in fine needle aspirates of breast lesions.
BACKGROUND The atypical category is controversial in fine needle aspiration cytology (FNAC) of the breast; most are benign, but a significant number are malignant. To date, no morphological criterion has been found to be consistent in predicting malignancy. AIMS To evaluate specific cytological parameters and assess their usefulness in predicting histological outcome in a cohort of atypical b...
متن کاملUltrastructural analysis of fine needle aspirates from benign breast lesions.
Thirty six fine needle aspirates from various types of benign breast lesions were examined by electron microscopy and correlated with their cytological appearances. In all cases the parenchyma consisted of clumps of cohesive cells with the ultrastructural features of epithelial cells. In many cases, particularly from fibroadenomas, the parenchyma consisted of single layers of polarised epitheli...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2004
ISSN: 0002-9173,1943-7722
DOI: 10.1309/x8up920uf4xm1c5c